Jun 27, 2025

Solve M.E., BIC, ChronicleBio, Complex Disorders Alliance & CareEvolution launch groundbreaking research partnership

This partnership unites decades of data, insights, and expertise to accelerate breakthroughs for millions affected by complex chronic conditions worldwide.

PRNewswire — Solve M.E., the Brain Inflammation Collaborative (BIC), ChronicleBio, the Complex Disorders Alliance, and CareEvolution have launched a powerful new collaboration to advance research on ME/CFS, Long COVID, and related conditions.

This partnership unites decades of data, insights, and expertise to accelerate breakthroughs. By sharing knowledge and building on existing work, it aims to deliver faster diagnoses, better treatments, and improved outcomes for the millions affected by these conditions worldwide.

Central to the collaboration is Solve M.E., a national nonprofit dedicated to making ME/CFS, Long Covid, and IACCIs widely understood, diagnosable, and treatable. Since 2010, Solve has collected patient-reported data, most recently through Solve Together — a dynamic platform created by CareEvolution. It allows users to track symptoms, sync wearables, generate reports for providers, and opt into clinical studies, and it's the largest database of its kind in the U.S.

The Brain Inflammation Collaborative, a patient-centered nonprofit, will take over the management of the Solve Together platform. BIC will expand the platform to include pediatric populations, additional diagnoses, and assessments aimed to illuminate the links between brain inflammation and mental health. The goal: more diverse and inclusive research across rural, marginalized, and underserved communities, with all materials translated into Spanish to further broaden access.

"This collaboration will ultimately benefit our growing patient communities and deliver the big breakthroughs they deserve," said Emily Taylor, CEO of Solve M.E. "It will allow for the collection and processing of more data from a broader population and ensure that principal investigators from multiple fields of study can access the open source data via a secure and vetted application process. By joining forces and tearing down research silos, we can leverage our shared resources to expedite progress and find treatments and cures for these complex conditions."

As part of the collaboration, Solve M.E. will share data with both the Complex Disorders Alliance — a patient-founded nonprofit that drives the development of diagnostics and treatments — and ChronicleBio, a biotech company advancing research on chronic illnesses including POTS, ME/CFS, and Long Covid. ChronicleBio will apply Solve's patient data to deepen insights and fuel transformative clinical trials.

Solve M.E.'s database is uniquely valuable for containing pre- and post-COVID-19 health information, enabling comparisons between individuals with ME/CFS triggered by COVID-19 and those with other origins. This insight helps researchers better understand how the pandemic has impacted long-term health.

"The Brain Inflammation Collaborative sees this collaboration and addition to our organization as a tremendous opportunity to catapult us to a place to immediately create meaningful research opportunities. We are very humbled and respectful of this opportunity and know the importance of doing justice to the work ahead of us," said Christy Jagdfeld, CEO of BIC.

Amy Rochlin, CEO of the Complex Disorders Alliance, added: "Patients cannot afford for us to work in silos or duplicate efforts. This partnership is about uniting — pooling data, insights, and expertise — to drive the breakthroughs that put patients first. By learning from one another and building on existing knowledge, we can turn research into real solutions — faster diagnoses, better treatments, and improved lives for those living with complex disorders."

Rohit Gupta, Co-Founder and CEO of ChronicleBio, stated: "There have been a number of barriers and promises made in bringing research findings to bedside. This collaboration aims to finally break down the silos and ensure each group is working in concert to drive new discoveries across medical, research, and advocacy. At the heart of our efforts is a mutual vision to empower those impacted by chronic illness, leading to more opportunities for all to be part of the path to cures."

A full roll-out of the new Solve Together platform under BIC leadership is expected in 2025.